Browse Channel
  • Articles
DOI: 10.12688/f1000research.9611.1
Revisiting inconsistency in large pharmacogenomic studies [version 1; referees: awaiting peer review]
Zhaleh Safikhani, Petr Smirnov, Mark Freeman, Nehme El-Hachem, Adrian She, Quevedo Rene, Anna Goldenberg, Nicolai J. Birkbak, Christos Hatzis, Leming Shi, Andrew H. Beck, Hugo J.W.L. Aerts, John Quackenbush, Benjamin Haibe-Kains
Referees: Invited
PUBLISHED 16 Sep 2016
DOI: 10.12688/f1000research.9471.1
Research Article
Whose sample is it anyway? Widespread misannotation of samples in transcriptomics studies [version 1; referees: 2 approved]
Lilah Toker, Min Feng, Paul Pavlidis
Referees: Leonard P. Freedman; Hans van Bokhoven
PUBLISHED 30 Aug 2016
DOI: 10.12688/f1000research.9448.1
Research Note
A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions" [version 1; referees: 1 approved]
Maxime Tarabichi, Vincent Detours
Referees: Benjamin Roche and Cindy Gidoin
PUBLISHED 22 Aug 2016
DOI: 10.12688/f1000research.9144.1
Research Note
A reanalysis of “Two types of asynchronous activity in networks of excitatory and inhibitory spiking neurons” [version 1; referees: 2 approved]
Rainer Engelken, Farzad Farkhooi, David Hansel, Carl van Vreeswijk, Fred Wolf
Referees: Jonathan Touboul; Maoz Shamir
PUBLISHED 22 Aug 2016
DOI: 10.12688/f1000research.9202.1
Research Article
Does sadness impair color perception? Flawed evidence and faulty methods [version 1; referees: 2 approved]
Alex O. Holcombe, Nicholas J. L. Brown, Patrick T. Goodbourn, Alexander Etz, Sebastian Geukes
Referees: Sophie von Stumm; Michael A Crognale
PUBLISHED 21 Jul 2016
DOI: 10.12688/f1000research.7822.2
Research Note
GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance [version 2; referees: 1 approved, 2 approved with reservations]
Jinghong Wang, Zheng Pan, Helene Baribault, Danny Chui, Caroline Gundel, Murielle Véniant
Referees: Mary Pelleymounter; Richard Neubig; Michelle Kimple
PUBLISHED 17 Jun 2016
DOI: 10.12688/f1000research.8731.1
Research Article
Results of an attempt to reproduce the STAP phenomenon [version 1; referees: 2 approved]
Shinichi Aizawa
Referees: Austin Smith; Irene de Lazaro
PUBLISHED 01 Jun 2016
DOI: 10.12688/f1000research.8753.1
Research Article
Early-childhood housing mobility and subsequent PTSD in adolescence: a Moving to Opportunity reanalysis [version 1; referees: 2 approved]
David C. Norris, Andrew Wilson
Referees: Ewout Steyerberg; Fred Hasselman
PUBLISHED 27 May 2016
DOI: 10.12688/f1000research.8705.1
Research Note
Assessment of pharmacogenomic agreement [version 1; referees: 3 approved]
Zhaleh Safikhani, Nehme El-Hachem, Rene Quevedo, Petr Smirnov, Anna Goldenberg, Nicolai Juul Birkbak, Christopher Mason, Christos Hatzis, Leming Shi, Hugo JWL Aerts, John Quackenbush, Benjamin Haibe-Kains
Referees: Weida Tong; Terence Speed; Yudi Pawitan
PUBLISHED 09 May 2016
DOI: 10.12688/f1000research.7800.2
Research Note
Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases? [version 2; referees: 3 approved]
Daniel Ortuno, Holly J. Carlisle, Silke Miller
Referees: Scott T Brady F1000Research Advisory Board member
; Thomas Kodadek F1000Prime Faculty Member
; Scott Wilson
PUBLISHED 25 Apr 2016
DOI: 10.12688/f1000research.8548.1
Research Article
Uptake of dietary milk miRNAs by adult humans: a validation study [version 1; referees: 3 approved]
Amanda Auerbach, Gopi Vyas, Anne Li, Marc Halushka, Kenneth Witwer
Referees: Cherie Blenkiron; Jens Allmer; Hervé Seitz
PUBLISHED 22 Apr 2016
DOI: 10.12688/f1000research.7868.2
Research Note
Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats [version 2; referees: 1 approved, 2 approved with reservations]
Songli Wang, Paul Wen, Stephen Wood
Referees: Sam Gandy; Mary Jo LaDu, Conor Smith and Ana Valencia; Daniel M. Michaelson
PUBLISHED 19 Apr 2016
DOI: 10.12688/f1000research.8236.1
Research Article
In search of the mechanisms of ketamine’s antidepressant effects: How robust is the evidence behind the mTor activation hypothesis [version 1; referees: 1 approved, 1 approved with reservations]
Susanna Popp, Berthold Behl, Jaya Julie Joshi, Thomas A. Lanz, Michael Spedding, Esther Schenker, Therese M Jay, Per Svenningsson, Dorian Caudal, Jacob I. Cunningham, Daniel Deaver, Anton Bespalov
Referees: John D. Graef; Eero Castrén and Plinio Casarotto
PUBLISHED 11 Apr 2016
DOI: 10.12688/f1000research.7847.1
Publishing confirming and non-confirming data [version 1; referees: not peer reviewed]
Bruce Alberts, Alexander Kamb
PUBLISHED 04 Feb 2016
DOI: 10.12688/f1000research.6555.2
Research Article
The Resource Identification Initiative: A cultural shift in publishing [version 2; referees: 2 approved]
Anita Bandrowski, Matthew Brush, Jeffery S. Grethe, Melissa A. Haendel, David N. Kennedy, Sean Hill, Patrick R. Hof, Maryann E. Martone, Maaike Pols, Serena Tan, Nicole Washington, Elena Zudilova-Seinstra, Nicole Vasilevsky, Resource Identification Initiative Members are listed here:
Referees: Randi Vita; William Gunn
PUBLISHED 19 Nov 2015
DOI: 10.12688/f1000research.6735.1
Research Note
Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome [version 1; referees: 2 approved]
Long H. Do, William C. Mobley F1000Prime Faculty Member
Nishant Singhal
Referees: Jon Pierce-Shimomura and Sarah Nordquist; Roger Reeves
PUBLISHED 17 Jul 2015
DOI: 10.12688/f1000research.6743.2
Research Article
Re-analysis of metagenomic sequences from acute flaccid myelitis patients reveals alternatives to enterovirus D68 infection [version 2; referees: 2 approved]
Florian P. Breitwieser, Carlos A. Pardo, Steven L. Salzberg F1000Prime Faculty Member
Referees: David Lipman F1000Prime Section Head
; Yoav Gilad
PUBLISHED 13 Jul 2015
DOI: 10.12688/f1000research.6536.1
Research Article
A reanalysis of mouse ENCODE comparative gene expression data [version 1; referees: 3 approved, 1 approved with reservations]
Yoav Gilad, Orna Mizrahi-Man
Referees: Rafael Irizarry; Michael Eisen F1000Prime International Advisory Board Member
; Mick Watson F1000Prime Faculty Member
; Lior Pachter
PUBLISHED 19 May 2015
DOI: 10.12688/f1000research.2-140.v1
Research Article
Environmental enrichment does not impact on tumor growth in mice [version 1; referees: 2 approved]
Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw
Referees: Marc Pellegrini F1000Research Advisory Board member
; Stephen Nutt F1000Prime Faculty Member
F1000Research Advisory Board member
PUBLISHED 12 Jun 2013

The Preclinical Reproducibility and Robustness channel is a platform for open and transparent publication of confirmatory and non-confirmatory studies in biomedical research. The channel is open to all scientists from both academia and industry and provides a centralized space for researchers to start an open dialogue, thereby helping to improve the reproducibility of studies. To see our advisory board please click here.

How does the channel work?

The channel is open for submission to all research scientists (academia and industry) who want to publish a confirming or non-confirming replication study on condition that they provide the full methodology and data to support their claims.

Each publication will undergo a fully transparent post-publication peer review following the F1000Research publication model. Referee reports from invited named experts will be posted alongside the article, allowing readers to get a full picture of the soundness of the replication experiments.

F1000Research recommends that authors raise any concerns about previous studies directly with the original authors before publishing their replication attempts. The authors whose studies have been confirmed or not confirmed can provide signed comments on the article, or publish their own full Correspondence article (which would also be openly peer-reviewed) in the channel if they have further (published or new) evidence that adds to the discussion (see our Correspondence article guidelines here).

The overall goal of the channel is to enable meaningful scientific discourse that is open and publicly available and aids the rapid progression of science.


Bruce Alberts University of California, San Francisco
Alexander Kamb Amgen Inc.
Sign In
If you've forgotten your password, please enter your email address below and we'll send you instructions on how to reset your password.

The email address should be the one you originally registered with F1000.

Email address not valid, please try again

You registered with F1000 via Google, so we cannot reset your password.

To sign in, please click here.

If you still need help with your Google account password, please click here.

You registered with F1000 via Facebook, so we cannot reset your password.

To sign in, please click here.

If you still need help with your Facebook account password, please click here.

Code not correct, please try again
Email for further assistance.
Server error, please try again.