NC3Rs
Method Article
metrics
Revised
Modelling host-Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids
[version 2; peer review: 2 approved]
Peer Reviewers
David Smith;
Maria Bernabeu
- Funders
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Wellcome Trust
Research Article
metrics
Measuring behaviour in hens using an ethogram to assess analgesia during further refinement of a high welfare, on-hen, poultry red mite feeding device
[version 1; peer review: 2 approved]
Peer Reviewers
Jan Perner and David Hartmann;
Mike J. McGrew
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Research Article
metrics
Feasibility and guidelines for the use of an injectable fiducial marker (BioXmark®) to improve target delineation in preclinical radiotherapy studies using mouse models.
[version 1; peer review: 1 approved, 2 approved with reservations]
Peer Reviewers
Emma Biglin;
Jane Sosabowski and Rebecca Carter;
Katrina Stevenson
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Research Article
metrics
Revised
Harmonisation of welfare indicators for macaques and marmosets used or bred for research
[version 3; peer review: 3 approved]
Peer Reviewers
Augusto Vitale;
Jan A. M. Langermans;
Kristine Coleman
Brief Report
metrics
Validating skin swabbing as a refined technique to collect DNA from small-bodied fish species
[version 1; peer review: 1 approved, 1 approved with reservations]
Peer Reviewers
Johan Ledin;
Marco Vindas
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
Revised
Development of liquid culture media mimicking the conditions of sinuses and lungs in cystic fibrosis and health
[version 2; peer review: 2 approved]
Peer Reviewers
Ville-Petri Friman;
Sheyda Azimi and Jelly Vanderwoude
- Funders
- Cystic Fibrosis Foundation
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Cystic Fibrosis Trust
Study Protocol
metrics
Registered report
Revised
Stage 1 Registered Report: Refinement of tickling protocols to improve positive animal welfare in laboratory rats
[version 2; peer review: 2 approved]
Peer Reviewers
Timothy M. Errington;
Theresa M. Kisko
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
Efficient embryoid-based method to improve generation of optic vesicles from human induced pluripotent stem cells
[version 1; peer review: 2 approved]
Peer Reviewers
Magdalene J. Seiler;
J. Arjuna Ratnayaka
- Funders
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Wellcome Trust
- Moorfields Eye Charity
Method Article
metrics
A population of in silico models identifies the interplay between Nav 1.8 conductance and potassium currents as key in regulating human dorsal root ganglion neuron excitability
[version 1; peer review: 1 approved, 3 approved with reservations]
Peer Reviewers
Dr. Gonzalo Hernandez Hernandez and Igor Vorobyov;
Stewart Heitmann;
Markos Xenakis;
Joseph J Pancrazio
- Funders
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Wellcome Trust
Method Article
metrics
Quantifying endothelial cell proliferation in the zebrafish embryo
[version 1; peer review: 1 approved, 2 approved with reservations]
Peer Reviewers
Christopher George;
Tzung Hsiai;
Stephen J. White
- Funders
- British Heart Foundation
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
Revised
The in vitro direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells
[version 2; peer review: 2 approved]
Peer Reviewers
Amanda J. Gibson;
Goletti Delia
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
An in vitro model for the cultivation of polymicrobial biofilms under continuous-flow conditions
[version 1; peer review: 2 approved]
Peer Reviewers
Daniel R. Neill;
Lindsay R. Kalan
- Funders
- Medical Research Council
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- British Lung Foundation
- Cystic Fibrosis Trust
Review
metrics
Revised
A review of experimental models of focal cerebral ischemia focusing on the middle cerebral artery occlusion model
[version 2; peer review: 2 approved]
Peer Reviewers
Lorraine M. Work;
Ruoli Chen
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
Revised
Isolation and primary culture of Galleria mellonella hemocytes for infection studies
[version 2; peer review: 2 approved]
Peer Reviewers
Lauren Ames;
Daniel R. Neill and Joanne L. Fothergill
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
The evaluation of feeding, mortality and oviposition of poultry red mite (Dermanyssus gallinae) on aging hens using a high welfare on-hen feeding device
[version 1; peer review: 2 approved]
Peer Reviewers
Cristian Magdas;
Antonio Camarda and Antonella Schiavone
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
Non-invasive somatotransgenic bioimaging in living animals
[version 1; peer review: 3 approved with reservations]
Peer Reviewers
Tingting Xu;
Antonius Plagge;
Felicity Gavins
- Funders
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- European Research Council
- Medical Research Council
Brief Report
metrics
Fast, easy and early (larval) identification of transparent mutant zebrafish using standard fluorescence microscopy
[version 1; peer review: 2 approved]
Peer Reviewers
Paul C. Evans;
Robert Hindges
- Funders
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Imperial College London
Method Article
metrics
Revised
A miRNA screen procedure identifies garz as an essential factor in adult glia functions and validates Drosophila as a beneficial 3Rs model to study glial functions and GBF1 biology
[version 2; peer review: 2 approved]
Peer Reviewers
Ivana Bjedov;
Jeff W. Barclay
- Funders
- Medical Research Council
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Ataxia UK
- Biotechnology and Biological Sciences Research Council
Method Article
metrics
Peer Reviewers
Pietro Mastroeni;
Claus-Michael Lehr and Patrick Carius;
Robert L Davies
- Funder
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
Method Article
metrics
An in vitro model for studying CNS white matter: functional properties and experimental approaches
[version 1; peer review: 2 approved]
Peer Reviewers
Tracey A. Newman;
Jacqueline Trotter
- Funders
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Multiple Sclerosis Society
The NC3Rs is a UK-based scientific organisation dedicated to replacing, refining and reducing the use of animals in research and testing. Follow us on twitter @NC3Rs. open_in_new