NC3Rs
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NOT PEER REVIEWED
The NC3Rs gateway: Accelerating scientific discoveries with new 3Rs models and technologies
[version 1; peer review: not peer reviewed]
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
Revised
Methodology for generating chorioallantoic membrane patient-derived xenograft (CAM-PDX) models of pleural mesothelioma and performing preclinical imaging for the translation of cancer studies and drug screening.
[version 2; peer review: 2 approved]
Peer Reviewers
Ulrich Jarry;
Stuart A. Clayton
- Funders
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- North West Cancer Research
Research Article
metrics
Registered report
Stage 2 Registered Report: Refinement of tickling protocols to improve positive animal welfare in laboratory rats
[version 1; peer review: 1 approved]
Peer Reviewers
Sergio Pellis
- Funder
- NC3Rs
Review
metrics
Revised
Application of transgenic zebrafish for investigating inflammatory responses to nanomaterials: Recommendations for new users
[version 2; peer review: 2 approved]
Peer Reviewers
Stephen Renshaw and Catherine Loynes;
Sijie Lin
- Funders
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Global Challenges Research Fund
- Engineering and Physical Sciences Research Council
Method Article
metrics
Generation of human iPSC-derived pancreatic organoids to study pancreas development and disease
[version 1; peer review: 2 approved, 3 approved with reservations]
Peer Reviewers
Christof Westenfelder;
Ilse Rooman;
Maria Cristina Nostro;
Mostafa Bakhti and Christos Karampelias;
Naoki Tanimizu
- Funders
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- Wellcome Trust PhD programme PhD studentship
Brief Report
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A Preclinical Model of Human Liver Using Precision Cut Tissue Slice Culture
[version 1; peer review: 2 approved, 1 approved with reservations]
Peer Reviewers
Raymond S W Yeung;
Sonam Gurung;
Una Rastovic and Elena Palma
- Funders
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- North West Cancer Research
Method Article
metrics
A humanised thrombus-on-a-chip model utilising tissue-engineered arterial constructs: A method to reduce and replace mice used in thrombosis and haemostasis research.
[version 1; peer review: 1 approved, 3 approved with reservations]
Peer Reviewers
Michael Emerson;
Navaneeth Krishna Rajeeva Pandian;
Kaushik N. Shankar;
Fahima Akther
- Funders
- British Heart Foundation
- Keele University Open Research grant
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
Validating the underpinnings of water corticosterone measurement for aquatic amphibians
[version 1; peer review: 2 approved]
Peer Reviewers
Sarah E. Westrick;
Nikolett Ujhegyi
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
Ex-vivo models of post-surgical residual disease in human glioblastoma
[version 1; peer review: 2 approved with reservations]
Peer Reviewers
Heiko Wurdak and Ryan Mathew Paul Chumas;
Karin Purshouse
- Funders
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- Yorkshire's Brain Tumour Charity
- The Brain Tumour Charity
- National Institute for Health and Care Research
- Royal College of Surgeons of England
Brief Report
metrics
Revised
Reduction of chickens use to perform in vitro pre-screening of novel anticoccidials by miniaturisation and increased throughput of the current Eimeria tenella compound-screening model
[version 2; peer review: 2 approved, 1 not approved]
Peer Reviewers
Benjamin Adjei-Mensah;
Joseph D. Turner;
Xiaokai Song
- Funder
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
Brief Report
metrics
Revised
Current status of immunodeficient mouse models as substitutes to reduce cat and dog use in heartworm preclinical research
[version 2; peer review: 4 approved]
Peer Reviewers
Constantin Constantinoiu;
Timothy G Geary;
Qian Han;
Jan Šlapeta
- Funders
- NC3R Skills & Knowledge Transfer Grant
- Welcome Trust Institutional Translational Partnership Award
- The UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)
Research Article
metrics
Revised
A survey of water chemistry used in zebrafish facilities and their effects on early zebrafish development
[version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]
Peer Reviewers
Lynne Sneddon;
Alex Zimmer;
Ziyu Guo;
Christopher Pierret
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Brief Report
metrics
Induction of torpor in response to a common chronic food restriction paradigm: implications for behavioural research using mice
[version 1; peer review: 1 approved, 1 not approved]
Peer Reviewers
Timna Hitrec;
Cara Green
- Funders
- Medical Research Centre
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Biotechnology and Biological Sciences Research Council
Brief Report
metrics
The effect of food timing on torpor propensity and characteristics in laboratory mice during a common food restriction paradigm
[version 1; peer review: 2 approved with reservations]
Peer Reviewers
Michael Ambler and William Wheatley;
Yoshifumi Yamaguchi and Satoshi Nakagawa
- Funders
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- Medical Research Centre
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Biotechnology and Biological Sciences Research Council
Method Article
metrics
Revised
A detailed methodology for a three-dimensional, self-structuring bone model that supports the differentiation of osteoblasts towards osteocytes and the production of a complex collagen-rich mineralised matrix
[version 3; peer review: 3 approved, 1 approved with reservations]
Peer Reviewers
Jesus Delgado-Calle and Hayley Sabol;
Holger Jahr;
Sabrina Ehnert;
Michelle A. Lawson
- Funders
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- Versus Arthritis
Method Article
metrics
Revised
Skin swabbing protocol to collect DNA samples from small-bodied fish species
[version 2; peer review: 2 approved]
Peer Reviewers
Luigi Margiotta-Casaluci;
Errol Cason
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
Revised
Ex-vivo drug screening of surgically resected glioma stem cells to replace murine avatars and provide personalise cancer therapy for glioblastoma patients
[version 2; peer review: 2 approved]
Peer Reviewers
Natividad Gomez-Roman;
Anke Brüning-Richardson
- Funders
- Urology Foundation
- Brain Tumour Charity
- Weston Park Cancer Charity
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Method Article
metrics
Revised
Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue model
[version 2; peer review: 2 approved, 1 approved with reservations]
Peer Reviewers
Claudia Crocini;
Emma Louise Robinson;
Mike Dodd
- Funders
- British Heart Foundation
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- European Union AFFECT-AF
- Academy of Medical Sciences
- Deutsche Forschungsgemeinschaft
- Fondation Leducq
- Medical Research Council
- MAESTRIA
Method Article
metrics
Revised
Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis
[version 2; peer review: 2 approved]
Peer Reviewers
Vivek Thacker;
Christopher Jon Hanley
- Funder
- National Centre for the Replacement Refinement and Reduction of Animals in Research
Brief Report
metrics
Revised
A human mesenchymal spheroid prototype to replace moderate severity animal procedures in leukaemia drug testing
[version 2; peer review: 2 approved]
Peer Reviewers
Simon E. Richardson;
Helen Wheadon
- Funders
- Children's Cancer and Leukaemia Group
- National Centre for the Replacement Refinement and Reduction of Animals in Research
- Wellcome Trust
Method Article
metrics
Revised
Co-cultures of cerebellar slices from mice with different reelin genetic backgrounds as a model to study cortical lamination
[version 2; peer review: 2 approved]
Peer Reviewers
Hector J. Caruncho and Brady Reive;
Pascale Chavis and Thomas Boudier
- Funder
- National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs)
The NC3Rs is a UK-based scientific organisation dedicated to replacing, refining and reducing the use of animals in research and testing. Follow us on twitter @NC3Rs. open_in_new